Current Open Cancer Clinical Trials
Researchers at New England Hematology/Oncology and Dana-Farber Cancer Institute are collaborating on a variety of studies that examine cancer in many different medical areas. Below is a list of clinical trials currently enrolling subjects.
(last updated September 2013)
A randomized phase III trial of the value of early local therapy for the intact primary tumor in patients with metastatic breast cancer
The aim of this study is to compare the possible benefits as well as the potential risks of a new approach that includes surgery and radiation to treat the tumor in the breast in addition to medication, versus the current standard approach (ie, medication to control the cancer that has spread).
A phase III randomized clinical trial of standard adjuvant endocrine therapy +/- chemotherapy in patients with 1-3 positive nodes, hormone receptor-positive and HER-2-negative breast cancer with recurrence score (RS) of 25 or less
The aim of this study is to determine whether the results from the Oncotype DX test can help determine who would benefit from chemotherapy and endocrine therapy and who would benefit from endocrine therapy alone.
A phase III clinical trial comparing trastuzumab given concurrently with radiation therapy and radiation therapy alone for women with HER-2-positive DCIS resected by lumpectomy
The aim of this study is to determine whether giving trastuzumab during radiation treatments is more beneficial in preventing breast cancer recurrence when compared with radiation treatments alone in women with HER-2-positive ductal carcinoma in situ (DCIS) resected by lumpectomy.
A phase III trial of accelerated whole breast irradiation with hypofractionation plus concurrent boost versus standard whole breast irradiation plus sequential boost for early stage breast cancer
The purpose of this study is to compare radiation therapy given with a higher daily dose over 3 weeks with a boost given each day of radiation therapy compared with standard whole breast radiation followed by a boost given on separate days which extends over 6 to 6 ½ weeks.
A three-arm, randomized, open label, phase II study of everolimus in combination with exemestane versus everolimus alone versus capecitabine in the treatment of postmenopausal women with estrogen receptor positive, locally advanced, recurrent, or metastatic breast cancer after recurrence or progression on prior letrozole or anastrozole
The purpose of the study is to compare the combination treatment of everolimus and exemestane to either everolimus alone, or capecitabine alone and to determine which of these three drugs, alone or in combination, better stabilizes or stops progression of breast cancer.
Helping ourselves, helping others: the young women’s breast cancer study
The aim of this study is to learn more about how breast cancer in young women affects their lives. We are particularly interested in young women’s emotional well-being, fertility concerns, sexual functioning, and physical health and treatment decisions.
Breast and Ovarian Cancer
Genetic and other causes of cancer. Risk evaluation and cancer history (REACH) questionnaire.
The REACH project collects risk factor information, blood and tissue specimens from patients and family members at high risk for breast and/or ovarian cancer. The data and specimen bank will be used as a resource to be shared with researchers working in the areas of breast and ovarian cancer risk, prevention and treatment.
Phase I/II trial of combination plerixafor (amd3100) bortezomib and dexamethasone in relapsed or relapsed/refractory multiple myeloma
The aim of this clinical trial is to determine how effective the combination of plerixafor, bortezomib and dexamethasone is on stopping myeloma cells from growing in patients who have relapsed or refractory myeloma.
A randomized, phase III study comparing conventional dose treatment using a combination of lenalidomide, bortezomib and dexamethasone (RVD) to high-dose treatment with peripheral stem cell transplant in the initial management of myeloma in patients up to 65 years of age
The aim of this research study is to explore the drug combination, lenalidomide, bortezomib and dexamethasone alone or when combined with autologous stem cell transplantation to see what side effects it may have and how well it works for treatment of newly diagnosed multiple myeloma.
A phase II, 2-stage, 2-arm PIK3CA mutation stratified trial of MK-2206 in recurrent or advanced endometrial cancer
The aim of this research study is to determine whether MK-2206 (a drug that may stop cancer cells from growing) is effective in treating recurrent and metastatic endometrial cancer and to see if participants whose tumors contain a particular genetic make-up will have a better response to MK-2206.
A phase III trial of 6 versus 12 treatments of adjuvant folfox plus celecoxib or placebo for participants with resected stage III colon cancer
One of the purposes of this study is to determine if giving participants both celecoxib (by mouth) and chemotherapy decreases the risk of colon cancer recurrence. The second purpose of this study is to determine whether giving 6 treatments of chemotherapy after surgery is as effective as giving the standard 12 treatments of chemotherapy.
Randomized, double-blind, phase II trial of vitamin d supplementation in patients with previously untreated metastatic colorectal cancer
The aim of this study is to to evaluate the efficacy and safety of two doses of vitamin D supplementation in combination with standard chemotherapy in participants with previously-untreated metastatic colorectal adenocarcinoma. Standard treatment includes the chemotherapy combination of 5-FU, Leucovorin and Oxaliplatin (FOLFOX) with bevacizumab.
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