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Home  Your Community Hospital For Medical Professionals For Physicians Current Study Spotlight: ...
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Current Study Spotlight: Osteoarthritis StudyCurrent Study SpotlightFrom Hope Violette, Manager, Office of Research February 2010 Principal Investigator: Dr. Henry DeGroot Study Name: A double-blind, randomized, placebo-controlled study of the relative efficacy of a single dose of hyaluronan in the treatment of osteoarthritis of the ankle. Study Aim: To compare the therapeutic effect of single intra-articular injection of hylauronate with single intra-articlular injection of normal saline (placebo) for osteoarthritis of the ankle. Funding: Funding for the research coordinator and for recruitment is through the COPE Fund, which is a NWH endowment fund for research. The remainder of the study is funded by Dr. DeGroot in an effort to keep the study unbiased. Background: Hyaluronate injections are safe and effective for the treatment of osteoarthritis of the knee. However, no randomized studies of this treatment in the ankle have been performed. Hyaluronans are glucosaminoglycans that are found in normal connective, epithelial, and neural tissues, a well as synovial fluid. The mechanism of action in the treatment of osteoarthritis is not fully understood, but is thought to include both viscosupplementation and anti-inflammatory effects. Viscosupplementation improves the lubrication of the treated joint, which decreases the stress and shear forces on the cartilage surfaces. In vivo models of osteoarthritis have demonstrated a chondroprotective role of hyaluronates. In studies of the synovial fluid of patients with osteoarthritis, hyaluronate injections have been shown to reduce the levels of inflammatory mediators. Eligibility Criteria:
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